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Department of Investigative Medicine, Imperial College, London

Department of Metabolic Medicine Publications - 1995 - 2000

Barnard ML, Schwieso JE, Thomas EL, Bell JD, Frost G, Bloom SR and Hajnal JV. Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution. NMR in Biomedicine 9: 156-164., 1996.

Beak SA, Small CJ, Ilovaiskaia I, Hurley JD, Ghatei MA, Bloom SR and Smith DM. Glucagon-Like Peptide-1 (GLP-1) Releases Thyrotropin (TSH): Characterization of Binding Sites for GLP-1 on ?-TSH Cells. Endocrinol 137: 4130-4138, 1996.

Bennet WM, Wang ZL, Jones PM, Wang R-M, James RF, London NJ, Ghatei MA and Bloom SR. Presence of neuropeptide Y and its messenger ribonucleic acid in human islets: evidence for a possible paracrine role. J Clin Endocrinol Metab 81: 2117-2120, 1996.

Bhogal R, Smith DM, Owji AA and Bloom SR. Can J Physiol Pharmacol 73: 1030-1036, 1996.

Bloom, S. R. and O'Shea D. Drugs in focus: 17. Octreotide. Prescribers' Journal 36(2), 120-124. 1996.

Bloom SR and Hammond P. Carcinoid Tumours. In: Molecular Endocrinology of Cancer, edited by Johnathan Waxman. Cambridge: Cambridge University Press, 1996, p. 318-343.

Choi SJ, Meeran K, O'Shea DB, Lambert PD and Bloom SR. Weight loss in rats treated with intracerebroventricular cobalt protoporphyrin is not specific to the neuropeptide Y system. Brain Res 729: 223-227, 1996.

Coppock HA, Owji AA, Bloom SR and Smith DM. Biochem J 318: 241-245, 1996.

Edwards AV, Tobin G, Ekstrom J and Bloom SR. Experimental Physiology 81: 349-359, 1996.

Frankton S and Bloom SR. Glucagonomas. In: Clinical Gastronenterology - International practice and research, edited by O'Shea D and Bloom SR. London: Bailliere Tindall, 1996, p. 697-705.

Gilligan MD, Marsonis A, Joshi J, Nihoyannopoulos P, Ghatei MA, Bloom SR and Oakley C. Cariovascular and hormonal responses to a meal in hypertrophic cardiomyopathy: a comparison of patients with and without postprandial exacerbation of symptoms. Clin Cardiol 19: 129-135, 1996.

Gunn, I., O'Shea, D. B., Turton, M. D., Beak, S. A., and Bloom, S. R. Central glucagon-like peptide-1 in the control of feeding. Regulatory peptides in the control of food intake and metabolism 24, 581-584. 1996.

Hammond PJ, Bloom SR and Polak JM. Hormones and the gastrointestinal tract. In: Oxford Textbook of Medicine, edited by Weatherall DJ, Ledingham JGG and Warrell DA. Oxford: Oxford University Press, 1996, p. 1891-1899.

Hammond PJ and Bloom SR. Non-diabetic pancreatic endocrine disorders and multiple endocrine neoplasia. In: Oxford Textbook of Medicine, edited by Weatherall DJ, Ledingham JGG and Warrell DA. Oxford: Oxford University Press, 1996, p. 1703-1710.

Hammond PJ, Smith DM, Akinsanya KO, Mufti WA, Wynick D and Bloom SR. Journal of Neuroendocrinology 8: 457-464, 1996.

Hoyt EC, Lund PK, Winesett DE, Fuller CR, Ghatei MA, Bloom SR and Ulshen MH. Effects of fasting, refeeding, and intraluminal triglyceride on proglucahgon expression in jejunum and ileum. Diabetes 45: 434-439, 1996.

Kulkarni RN, Smith DM, Ghatei MA, Jones PM and Bloom SR. Investigation of the effects of antisense oligodeoxynucleotides to islet amyloid polypeptide mRNA on insulin release, content and expression. J Endocrinol 151: 341-348, 1996.

Morgan DGA, Lambert PD, Smith DM, Wilding JPH and Bloom SR. Journal of Neuroendocrinology 8: 283-290, 1996.

Nandha KA, Taylor GM, Smith DM, Owji AA, Byfield PGH, Ghatei MA and Bloom SR. Regul Pept 62: 145-151, 1996.

Nightingale JMD, Kamm MA, Ghatei MA, Bloom SR and Lennard-Jones JE. Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying. Gut 39: 267-272, 1996.

O'Shea D, Bloom SR and Wiliamson RCN. Endocrine tumours. In: Management of Gastrointestinal Cancer, edited by McCulloch P and Kingsnorth A. London: BMJ Publishing, 1996, p. 300-320.

O'Shea DB, Gunn I, Chen X, Bloom SR and Herbert J. A role for central glucagon-like peptide-1 in temperature regulation. NeuroReport 7: 830-832, 1996.

O'Shea DB, Rohrer-Theus AW, Lynn JA, Jackson JE and Bloom SR. Localization of insulinomas by selective intraarterial calcium injection. J Clin Endocrinol Metab 81: 1623-1627, 1996.

Oka M, Khandan Nia N, Jones P, Ghatei M and Bloom SR. Biomedical Research 16: 281-286, 1996.

Owji AA, Gardiner JV, Upton PD, Mahmoodi M, Ghatei MA, Bloom SR and Smith DM. Journal of Neurochemistry 67: 2172-2179, 1996.

Playford RJ, Boulton R, Ghatei MA, Bloom SR, Wright NA and Goodlad RA. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion 57: 362-367., 1996.

Taylor GM, Meeran K, O'Shea DB, Smith DM, Ghatei MA and Bloom SR. Endocrinol 137: 3260-3264., 1996.

Thomas EL, Frost G, Barnard ML, Bryant D, Taylor-Robinson SD, Simbrunner J, Coutts GA, Burl M, Bloom SR, Sales KD and Bell JD. An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition. Lipids 31: 145-151, 1996.

Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J and Bloom SR. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379: 69-72, 1996.

Ulshen MH, Hoyt EC, Fuller CR, Ghatei MA, Bloom SR and Lund PK. Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth. Dig Dis Sci 41: 677-683, 1996.

Zhao L, Brown LA, Owji AA, Nunez DJR, Smith DM, Ghatei MA, Bloom SR and Wilkinson MR. Amer J Physiol 271: H622-H629, 1996.

Akinsanya K, Jamal H, Ghatei MA and Bloom SR. J Endocrinol 145: 333-341, 1997.

Akinsanya, K., griffiths A, J, Wang, Z., Wynick, D., and Bloom, S. R. Paracrine control of the islet and pituitary - a model system for regulatory peptides. Proceedings of the 77th Falk Symposium , 95-112. 1997.

Bloom, S. R. and et-al. Glucagon-like peptide-1 and satiety. Nature 385, 214. 16-1-1997.

Bowman ECJ, Roderick GP, Bloom SR and Edwards AV. Am J Physiol 272: R607-R614, 1997.

Changani KK, Barnard ML, Bell JD, Thomas EL, Williams SC, Bloom SR and Iles RA. Biochim Biophys Acta 290-304, 1997.

Desai M, Byrne CD, Meeran K, Martenz ND, Bloom SR and Hales CN. The American Physiological Society G899-G904, 1997.

Domin J, Miguel A, Benito-Orfila MA, Nandha KA, Aitken A and Bloom SR. The purification and sequence analysis of an avian neuromedin U. Regul Pept 41: 1-8, 1997.

Edwards AV, Bloom SR and Ghatei MA. Experimental Physiology 717-727, 1997.

Edwards CMB, Edwards AV and Bloom SR. Experimental Physiology 82: 709-716, 1997.

Gardiner JV, Mahmoodi M and Bloom SR. Long-term culture of galanin expressing encapsulated RIN 1056a cells in vitro. Transplant Proc 29: 2019-2020, 1997.

Ghatei M.A., Ratcliffe B, Bloom SR and Goodlad RA. Clin Sci 93: 109-112, 1997.

Goldstone AP, Mercer JG, Gunn I, Moar KM, Edwards CM, Rossi M, Howard JK, Rasheed S, Turton MD, Small CJ, Heath MM, O'Shea D, Steere J, Meeran K, Ghatei MA, Hoggard N and Bloom SR. FEBS Letters 415: 134-138, 1997.

Gunn I, O'Shea D and Bloom SR. Control of appetite - the role of glucagon-like peptide-1 (7-36) amide. Journal of Endochrinology 197-200, 1997.

Hammond PJ, Khandan Nia N, Withers DJ, Jones PM, Ghatei MA and Bloom SR. Regulation of anterior pituitary galanin and vasoactive intestinal peptide by oestrogen and prolactin status. J Endocrinol 152: 211-219, 1997.

Hanna, Smith DM, Johnston C F, Akinsanya K, Jackson M L, Morgan DGA, Bhogal R, Buchanan K and Bloom SR. Expression of a Novel Receptor for the Calcitonin Peptide Family and a Salmon Calcitonin-Like Peptide in the Thyrotropin Thyroytroph Cell Line. Endocrinol 95: 0013-7227, 1997.

Janmohamed, S. and Bloom, S. R. Carcinoid tumours. Postgraduate Medical Journal 73, 207-214. 1997.

Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ and Bloom SR. J Clin Invest 100 (11): 2729-2736, 1997.

Meeran K, O'Shea DB, Upton PD, Smith C, Ghatei MA, Byfield PGH and Bloom SR. Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: a pharmacokinetic study. J Clin Endocrinol Metab 82: 1-6, 1997.

O'Shea DB, Morgan DGA, Meeran K, Edwards CMB, Turton MD, Choi SJ, Heath MM, Gunn I, Taylor GM, Howard JK, Small CJ, Smith DM, Ghatei MA and Bloom SR. Endocrinol 138: 196-202, 1997.

Redington AE, Springal DR, Ghatei MA, madden J, Bloom SR, frew AJ, Polak JM, Holgate ST and Howarth PH. Airway endothelin levels in asthma: influence of endobronchial allergen challenge and maintenance corticosteroid therapy. Eur-Respir-J 10: 1026-1032, 1997.

Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA and Bloom SR. Melanin-Concentrating Hormone Acutely Stimulates Feeding, But Chronic Administration Has No Effect on Body Weight. Endocrinol 138: 351-355, 1997.

Small CJ and Bloom SR. Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. PNAS 94: 11686-11691, 1997.

Sunter, D., O'Shea, D., and Bloom, S. R. Leptin and recent advances in appetite regulation. Tumour Marker Update 9(1), 1-4. 1997.

Tobin G, Edwards AV, Bloom SR and Ekström J. Experimental Physiology 825-836, 1997.

Todd JF, Wilding JP, Edwards CM, Khan FA, Ghatei MA and Bloom SR. Glucagon-like peptide-1 (GLP-1): a trial of treatment in non-insulin- dependent diabetes mellitus. Eur J Clin Invest 27: 533-536, 1997.

Turton, M. D., O'Shea, D., and Bloom, S. R. Central effects of Neuropeptide Y with emphasis on its role in obesity and diabetes. Peptides 12, 3040990-3040993. 1997.

Upton PD, Austin C, Taylor GM, Nandha KA, Clark AJ, Ghatei M.A., Bloom SR and Smith DM. Endocrinol 138: 2508-2514, 1997.

Wang ZL, Rohit N, Kulkarni RN, Wang R-M, Smith DM, Ghatei M.A., Byfield PGH, Bennet WM and Bloom SR. Possible evidence for Endogenous Production of a novel galanin-like peptide. J Clin Invest 100: 189-196, 1997.

Wilding JPH, Ajala MO, Lambert PD and Bloom SR. J Endocrinol 152: 365-369, 1997.

Withers DJ, Coppock HA, Seufferlein T, Smith DM, Bloom SR and Rozengurt E. Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells. FEBS Letters 378: 83-87, 1997.

Beak SA, Heath MM, Small CJ, Morgan DGA, Ghatei M.A., Taylor AD, Buckingham JC, Bloom SR and Smith DM. J Clin Invest 101: 1334-1341, 1998.

Brynes AE, Frost G, Edwards CMB, Ghatei M.A. and Bloom SR. Plasma Glucagon-Like Peptide-1 (7-36) Amide (GLP-1) Response to Liquid Phase, Solid Phase, and Meals of Differing Lipid Composition. Nutrition 14: 433-436, 1998.

Edwards CMB, Todd JF, Ghatei M and Bloom SR. Subcutaneous glucagon-like peptide-1 (7-36) amide is insulinotropic and can cause hypoglycaemia in fasted healthy subjects. Clinical Science 96: 719-724, 1998.

Geohegan, J. G., Emberton, M., Bloom, S. R., and Lynn, J. A. Changing trends in the management of phaeochromocytoma. Br-J-Surg. 85, 117-120. 1-1-1998.

Howard JK, Lord GM, Clutterbuck EJ, Ghatei MA, Pusey CD and Bloom SR. Plasma immunoreactive leptin concentration in end-stage renal disease. Clinical Science 93: 119-126, 1998.

Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR and Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897-902, 1998.

Morgan DGA, Kulkarni RN, Hurley JD, Wang ZL, Wang RM, Ghatei MA, Karlsen AE and Bloom SR. Diabetologia 41: 1482-1491, 1998.

Morgan DGA, Small CJ, Abusnana S, Turton M, Gunn I, Heath M, Rossi M, Goldstone AP, O'Shea D, Meeran K, Ghatei M, Smith DM and Bloom SR. The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism. Regul Pept 75-76: 377-382, 1998.

O'Shea D, Wynick D and Bloom SR. Islet-cell tumours (excluding insulinomas and carcinoids). In: Clinical Endocrinology, edited by Grossman A. Blackwell Science, 1998, p. 540-548.

Playford RJ, Marchbank T, Mandir N, Higham A, Meeran K, Ghatei M.A., Bloom SR and Goodlad RA. Effects of Keratinocyte Growth Factor (KGF) on Gut Growth and Repair. J Pathol 184: 316-322, 1998.

Polak, J. and Bloom, S. R. The neuroendocrine system and its tumours. Cellular & Molecular Biology of Cancer Third Edition, 299-310. 1998.

Roberts GA, Holt RIG, Ghatei M.A., Baker AJ, Bloom SR and Miell JP. Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation. Clin Endocrinol 48: 401-406, 1998.

Rossi M, Kim MS, Morgan DGA, Small CJ, Edwards CMB, Sunter D, Abusnana S, Goldstone AP, Russell SH, Stanley SA, Smith DM, Yagaloff K, Ghatei MA and Bloom SR. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinol 139: 4428-4431, 1998.

Rossi M and Bloom SR. Control of Appetite. In: Horizons in Medicine, edited by Savill J. Royal College of Physicians, 1998, p. 163-170.

Small CJ, Todd JF, Ghatei M, Smith DM and Bloom SR. Neuropeptide Y (NPY) actions on the corticotroph cell of the anterior pituitary gland are not mediated by a direct effect. Regul Pept 75-76: 301-307, 1998.

Small, C. J. and Bloom, S. R. Neuropharmacology. Cheap date [news; comment]. Nature 396(6709), 313-314. 26-11-1998.

Todd JF, Edwards CMB, Ghatei MA, Mather HM and Bloom SR. Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early Type 2 diabetes. Clinical Science 95: 325-329, 1998.

Todd JF, Small CJ, Akinsanya KO, Stanley SA, Smith DM and Bloom SR. Endocrinol 139: 4222-4229, 1998.

van dS, Jr., Kamm MA, Nightingale JM, Akkermans LM, Ghatei MA, Bloom SR, Jansen JB and Lennard-Jones JE. Circulating gastrointestinal hormone abnormalities in patients with severe idiopathic constipation. Am J Gastroenterol 93: 1351-1356, 1998.

Wynick, D., Small, C. J., Bloom, S. R., and Pachnis, V. Targeted disruption of the murine galanin gene. Annals of the New York Academy of Sciences 863, 22-47. 21-12-1998.

Wynick D, Small CJ, Bacon A, Holmes FE, Norman M, Ormandy CJ, Kilic E, Kerr NCH, Ghatei M, Talamantes F, Bloom SR and Pachnis V. Galanin regulates prolactin release and lactotroph proliferation. PNAS 95: 12671-12676, 1998.

Coppock HA, Owji AA, Austin C, Upton PD, Jackson ML, Gardiner JV, Ghatei MA, Bloom SR and Smith DM. Biochem J 338 ( Pt 1): 15-22, 1999.

Edwards, C. M. and Bloom, S. R. GLP-1 and Obesity. Neuroscience News (Focus on Obesity) 2(6), 33-36. 1999.

Edwards CM, Ghatei MA, Bloom SR and Edwards AV. Experimental Physiology 84: 1107-1113, 1999.

Edwards, C. M. B and Bloom, S. R. The Incretins - outdated terminology in man ? Diabetologia 42(9), 1148. 1999.

Edwards CMB, Todd JF, Mahmoudi M, Wang Z, Wang RM, Ghatei MA and Bloom SR. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans. Diabetes 48: 86-93, 1999.

Edwards, C. M. B., Cohen, M. A., and Bloom, S. R. Peptides as drugs. Quarterly Journal of Medicine 92(1), 1-4. 1999.

Edwards CMB, Abusnana S, Sunter D, Murphy JK, Ghatei M.A. and Bloom SR. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 160: R7-R12, 1999.

Howard JK, Lord GM, Matarese G, Vendetti, Ghatei MA, Ritter, Lechler RI and Bloom SR. J Clin Invest 104: 1051-1059, 1999.

Jordinson M, Goodlad RA, Brynes A, Bliss P, Ghatei MA, Bloom SR, Fitzgerald A, Grant G, Bardocz S, Pusztai A, Pignatelli M and Calam J. Am J Physiol 276: G1235-G1242, 1999.

Makker HK, Springall DR, Redington AE, Ghatei MA, Bloom SR, Polak JM, Howarth PH and Holgate ST. Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge. Clinical & Experimental Allergy 29: 241-247, 1999.

Meeran K, O'Shea D, Edwards CMB, Turton MD, Heath MM, Gunn I, Abusnana S, Rossi M, Small CJ, Goldstone AP, Taylor GM, Sunter D, Steere J, Choi SJ, Ghatei MA and Bloom SR. Endocrinol 140: 244-250, 1999.

Nandha KA, Benito-Orfila MA, Jamal H, Akinsanya K, Bloom SR and Smith DM. Effect of steroids and the estrous cycle on uterine neuromedin U receptor expression. Peptides 20: 1203-1209, 1999.

Rossi M, Beak SA, Choi SJ, Small CJ, Morgan DGA, Ghatei M, Smith DM and Bloom SR. Investigation of the feeding effects of melanin concentrating hormone on food intake - action independent of galanin and the melanocortin receptors. Brain Res 846: 164-170, 1999.

Stanley SA, Small CJ, Kim MS, Heath MM, Seal LJ, Russell SH, Ghatei MA and Bloom SR. Endocrinol 140: 5459-5462, 1999.

Taheri S, Mahmoodi M, Opacka-juffry J, Ghatei MA and Bloom SR. FEBS Lett 457: 157-161, 1999.

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